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2022 NFL Week 1 Schedule

NFL Week 1 2022 Preview and Sportsbook Management

The first game of the 2022-2023 NFL Season is here. NFL week 1 started on September 8, as the Buffalo Bills travel to SoFi Stadium in Inglewood, California, to take on the SB champion Los Angeles Rams. Keep reading for odds, analysis, and everything pay per head agents require to have a successful and profitable first week in the new NFL season. 

NFL Week 1 kicks off what promises to be an exciting and unpredictable season of professional football. On Thursday, September 8, the Buffalo Bills head to Los Angeles to take on the Rams.

The Bills will enter SoFi Stadium not only as the favorite to win the game but also the chalk to win the championship. 

The first Sunday night game pits Tom Brady and Tampa Bay versus Dak Prescott and the Dallas Cowboys. Week 1’s Monday game shows Russell Wilson traveling back to Seattle to take on the Seahawks. 

Keep reading for what bookie betting agents must know about every NFL Week 1 matchup.

2022 NFL Week 1 Schedule

  • When: Thursday, September 8 – Monday, September 12

Bookmaker Software Tips for the NFL’s First Regular Season Week

NFL Week 1 Thursday Night Football – September 8

Buffalo Bills -2.5 at Los Angeles Rams  

A week before kickoff, close to 70% of players prefer the Bills to cover versus the Rams. LAR starting quarterback Matthew Stafford is dealing with an elbow issue.

Not only that, but two of the Rams’ top defenders, linebacker Leonard Floyd and Jalen Ramsey, are questionable. Buffalo figures to cover. 

Consider: Placing betting limits on Buffalo’s moneyline and spread line. Also, set max limits on the Rams’ ML since this happens on their field.   

NFL Week 1 – Sunday, September 11

New Orleans Saints -5.5 at Atlanta Falcons

Although NFL handicappers favor the Saints to cover, it’s by a slim margin. 56% are on New Orleans. 44% are on the Falcons.

Head-to-head trends say the Saints cover. New Orleans is 4-0 in the last four meetings between these two in Atlanta. The road team in this series is 5-1 in the previous six head-to-head.  

Consider: Max limits on all available bets, especially on the Falcons’ moneyline, is a prudent move. 

San Francisco 49ers -6.5 at Chicago Bears

The Bears were so desperate to add depth to their offensive line that they snatched up former first-round Raiders’ draft pick Alex Leatherwood hours after Las Vegas cut him. 

Showing desperation a week before dealing with superb skill player Deebo Samuel and SF quarterback Trey Lance isn’t a good sign. But this is the first time Lance is the unquestioned main dude in the Bay Area.

Consider: Bookmaker software agents, including you, should see some action on the Bears to cover. Use your layoff account if required. 

Pittsburgh Steelers at Cincinnati Bengals -6.5

Cincinnati put effort into rebuilding the right side of their offensive line. A week before this game, Pittsburgh coach Mike Tomlin has yet to say who he’s starting at quarterback.

It shouldn’t matter who it is. But although the Bengals figure to cover, this is a rivalry game, and Steelers outside linebacker T.J. Watt, the 2021 NFL Defensive Player of the Year, will play. 

Consider: Pay per head sportsbook agents should see some action on the Steelers’ to win this straight up. Rivalry games often end in close affairs. Use the layoff account and set max limits on the Steelers.    

Philadelphia Eagles -3.5 at Detroit Lions

On paper, the Eagles should roll. The Lions, though, drafted the favorite to win this season’s NFL Defensive Rookie of the Year award.

Defensive end Aidan Hutchinson will press Eagles’ QB Jalen Hurts. The line implies a close game.

Consider: The Eagles are the better overall team in this game. Home field could mean something. Place max limits on the Lions’ moneyline. 

New England Patriots at Miami Dolphins -2.5

Patriots quarterback Mac Jones appeared out of sorts in the first week of training camp. But Mac has gotten much more comfortable with the new offensive system.

Miami QB Tua Tagovailoa will benefit big time from Mike McDaniel, San Francisco’s former offensive coordinator and the Dolphins’ new head coach, calling plays. Still, it’s tough to go against a Bill Belichick-coached defense facing a rival in NFL Week 1. 

Consider: It’s always a good idea to set max limits when the Pats take on the Fins, the Jets, or the Bills. History tells us Belichick owns New England’s division rivals. 

Baltimore Ravens -6.5 at New York Jets

The Ravens head to New York to battle the Jets in what should be a more exciting game than many believe. Baltimore doesn’t always step it up on the road.

Not only that, but the Jets’ defense should be decent in 2022. 

Consider: Only 20% of NFL handicappers prefer the Jets to cover because Zach Wilson, J-E-T-S’s QB1, may not put on the pads. NYJ is home, so betting program agents should set max limits.  

Jacksonville Jaguars at Washington Commanders -3.5

The Jaguars offer overlay odds both against the spread and to win this SU. Because this happens at FedEx Field, many believe DC gets it done. But the Commanders’ defense will be missing Chase Young. 

So the Jags might have the better D in this matchup. In addition, some NFL bettors will side with Jacksonville quarterback Trevor Lawrence as the better signal-caller than Washington QB Carson Wentz.    

Consider: The Jaguars offer overlay odds both against the spread and to win this SU. Sports betting agent bookies know the drill. Set those max limits.  

Cleveland Browns at Carolina Panthers -2.5

The Browns must play the first 11 games without starting quarterback Deshaun Watson. While Watson sits on the bench, Cleveland will play Jacoby Brissett. 

Brissett is a decent backup quarterback. Carolina traded for former Cleveland starter Baker Mayfield. If Baker wants to make the most he can this season; he must play lights out. There’s a good chance Baker proves to his former employers they made the wrong decision by giving up on him. 

Consider: Price per head bookies should set max limits on the Panthers to cover. More than 76% of pro football handicappers are backing Carolina. 

Indianapolis Colts -8.5 at Houston Texans

The Colts acquired Matt Ryan to play quarterback. Ryan is an upgrade over Carson Wentz. 

However, Matty Ice is 37 years old. So, although it looks like he should have no trouble carving up Houston’s defense, we won’t know until the Colts and Texans play. 

Consider: The Colts should rout the Texans, but this line feels off for some reason. Yes, 61% back Indy to cover. Sure, Houston might have the worst roster in the NFL. The Texans’ ML is outrageous, though. So set max betting limits for sure.  

New York Giants at Tennessee Titans -5.5

So far, the Giants’ are loving Brian Daboll. NYG’s new head coach has brought the same creativity he showed with the Buffalo Bills to the Giants. 

However, Daboll and the G-Men may be up against it on September 11. The Titans’ roster looks much better. Also, Tennessee had a quiet training camp, which means it was a good training camp. 

Consider: Action on the Titans should continue because 3 of the Giants’ offensive linemen list as questionable. So are starting wide receiver Kadarius Toney, starting tight-end Daniel Bellinger, and three of New York’s starters in their front seven. Bookie website agents should use their layoff account if they must.      

Green Bay Packers -2.5 at Minnesota Vikings

Green Bay is a -2.5 favorite. So far, 58% of NFL handicappers prefer the Packers. That could change after some players realize the Vikings have an excellent offense.

Also, this happens in Minnesota, and Aaron Rodgers isn’t sure who his top target will be this season after Davante Adams bolted to play for the Vegas Raiders.  

Consider: Packers versus Vikings should be one of NFL Week 1’s most competitive games. Use the layoff account if you must. 

Kansas City Chiefs -3.5 at Arizona Cardinals

NFL bettors are all over the Kansas City Chiefs. Your players may not back KC as much as the public. 

AZ will be without DeAndre Hopkins, and they should lose, but this feels like one of those the half a point means something games. So Patrick Mahomes and his fellas could win this by three and not cover. 

Consider: The Cardinals take on KC at home. Also, last season Zona won their first seven games in a row. That shouldn’t happen in 2022, but since Kliff Kingsbury will send out a well-prepared squad, limits on the Arizona moneyline makes sense. 

Las Vegas Raiders at Los Angeles Chargers -3.5

At -3.5, the Bolts might be an overlay. The Raiders should be a good team this season. But there are multiple red flags regarding Las Vegas’ offensive line. 

Right now, many believe Las Vegas keeps this under the number. That could change the more info comes out regarding how bad the Raiders’ O-line could end up being this season. 

Consider: Wait for action and then use the layoff account if required. If more action ends up on the Raiders, and you believe Las Vegas’ offensive line is a liability, consider not laying off the total amount. 

Tampa Bay Buccaneers -1.5 at Dallas Cowboys 

The first Sunday night game pits two teams that supposedly can win the 2023 Super Bowl. Tampa must travel to Dallas this season.

In last season’s game, the Cowboys pushed the Buccaneers. Tom Brady must play behind an offensive line that includes three new starters this season. Dallas has a real chance of winning this game straight up. 

Consider: The most competitive game in NFL Week 1 based on odds can go either way. Use the layoff account no matter where the money lands.   

NFL Week 1 Monday Night Football – September 12

Denver Broncos -6.5 at Seattle Seahawks 

Seattle’s roster isn’t close to Denver’s. But many players will look at the odds and refuse to lay the -6.5.

Others will go with Russell Wilson to dominate. Russ just signed a massive 5-year deal that will pay him a ridiculous $245 million with $165 mil guaranteed. So Wilson will be motivated to show up against his former team.

Consider: The Broncos should easily cover the spread. But this is a Denver road tilt. Set max limits on the Seahawks moneyline. Also, use the layoff account if too much action lands on the Ponies. 

Like every NFL week, NFL Week 1 has its fair share of pitfalls. Sportsbook software agents should use available tools to make as much money as possible.

If you have to sign with PayPerHead, do so soon. With our latest promo, you can get up to 3 months’ cash back. We also boosted our referral program so that you can make up to 17% each month on your referred friends’ deposits.

Also, we’ll handle transferring your book for you. Call 1-800-605-4767 and start today.   

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